Early ADME & DMPK screening
Solubility, permeability, plasma protein binding, blood-to-plasma ratio, metabolic stability, and other candidate-screening assays.
DMPK, ADME & Pharmacokinetics Studies
Integrated ADME, DMPK, and pharmacokinetic studies to characterize absorption, distribution, metabolism, excretion, exposure, and drug-interaction potential before candidate advancement.
Understand exposure and disposition across the program.
DMPK strategy can begin with rapid in vitro ADME screening and extend into in vivo pharmacokinetics, bioavailability, tissue distribution, mass balance, metabolite profiling, and enzyme or transporter studies. Scope is matched to the molecule, modality, and development question.
Early studiesADME, Stability, Permeability
In vivo studiesPK, Exposure, Distribution
Mechanistic workMetabolites, Enzymes, Transporters
DMPK and pharmacokinetics capabilities.
In vivo pharmacokinetics
Single- or repeat-dose PK studies using project-appropriate species, routes, matrices, sampling schedules, and bioanalytical methods.
Bioavailability & distribution
Systemic exposure, absolute or relative bioavailability, tissue distribution, and target-tissue exposure where required.
Mass balance & excretion
Recovery and excretion-route assessment with study format and analytical approach confirmed for the specific program.
Metabolite profiling
Metabolite identification, cross-species comparison, metabolic pathway assessment, and selected metabolite exposure.
Enzymes & transporters
CYP inhibition or induction, reaction phenotyping, transporter substrate or inhibition studies, and drug-interaction risk assessment.
Common DMPK and PK outputs.
Exposure
Concentration-time profiles and parameters such as Cmax, Tmax, AUC, half-life, clearance, and volume of distribution.
Absorption & distribution
Bioavailability, permeability, protein binding, blood partitioning, and tissue exposure.
Metabolism
Metabolic stability, metabolite identity and abundance, enzyme contribution, and cross-species comparison.
Excretion & interaction
Mass balance, excretion routes, transporter activity, and enzyme- or transporter-mediated interaction potential.
Assay availability, species, analytical method, sampling design, timelines, and deliverables are confirmed during technical review.
What defines a fit-for-purpose DMPK plan.
- Molecule type, physicochemical properties, and formulation
- Development stage and decision criteria
- Species, dose route, dose level, and sampling design
- Biological matrix and bioanalytical requirements
- Metabolite, enzyme, transporter, or interaction questions
- Required data tables, interpretation, and reporting format
Need an ADME, DMPK, or PK study plan?
Share the compound, development stage, known properties, intended route, and decision question. We can coordinate the appropriate screening and in vivo study sequence.Required fields are marked with an asterisk(*).