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Continuous Processing

Flow Chemistry

Continuous thinking for ambitious molecules.

From feasibility loops to validated trains, our engineers tune residence time, mixing, and control strategies for demanding reactions.

From concept loop to validated train

Every continuous process begins with feasibility sprints and scales through modular assets, so the same strategy can carry a molecule from microreactor proof to cGMP production.

Continuous flow reactor skids with inline monitoring equipment.
Stage 1

Screen

Chip-scale reactors test residence time, heat, and mass transfer assumptions within days.

Stage 2

Design

Modular skid configurations are simulated and tweaked before fabrication begins.

Stage 3

Prove

Pilot trains integrate PAT, inline quench, and work-up to demonstrate repeatable performance.

Stage 4

Launch

GMP trains lock validated recipes with redundancy plans and change-control triggers.

Control levers we engineer into every flow process

Residence time orchestrationAutomated flow controllers and pressure sensors keep critical reactions inside narrow operating windows.
Thermal stabilityHigh-surface-area heat exchangers avoid hotspots in exothermic chemistries and unlock extreme temperature profiles.
Inline analyticsPAT toolkits — UV, IR, MS, and Raman — verify conversion and impurity build-up in real time.
Rapid changeoverSkids are designed with clean-in-place recipes and modular manifolds, keeping turnaround between campaigns short.
Safety interlocksIntegrated relief systems, automated shutdowns, and secondary containment keep operators protected even with hazardous feeds.

When flow chemistry is the right answer

Fast kineticsExtremely short reaction times get the control they need from precise residence time management.
Hazardous reagentsMicroreactors and small holdup volumes keep energetic or toxic species contained.
Quality at scaleContinuous operation delivers batch-to-batch consistency and simplifies validation.
TECHNOLOGY PLATFORMS

Technology platforms for complex chemistry.

Choose the chemistry platform that fits your route, containment, stereochemistry, biology-enabled process, or digital collaboration needs.

Abstract connected technology platform network for complex chemistry
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Discuss Your Project

Tell us what you need to make, source, or scale. Our team will route your request to the right specialist.

Product sourcing
Custom synthesis
Scale-up support
info@dempochem.com
Westerstraat 10, 3016 DH, Rotterdam, Netherlands
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