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Stereochemical Precision

Chiral Synthesis

Routes that respect every stereocentre.

We treat chirality as a design constraint, building asymmetric routes that stand up to scale-up, validation, and commercial scrutiny.

From discovery briefing to launch stock

Route scouting starts with the business goal in mind: deliver the right enantiomer with predictable cost-of-goods. We combine computational screening with lab experience to prioritise catalytic pathways before touching kilo quantities.

  • Parallel screening for ligands, solvents, and bases to lock in optimal selectivity early.
  • Integrated analytical support with chiral HPLC, UPC2, and qNMR running beside the chemists.
  • Tech-transfer packages that document catalyst life, impurity fate, and crystallisation behaviour.
>95% eevalidated across pilot and commercial scale campaigns
3xparallel screening lanes during asymmetric route scouting
<6 weeksmedian time to deliver a full asymmetric route package
Laboratory glassware capturing the precision required for chiral synthesis workflows.

Instrumentation we lean on

Analytical control anchors every chiral decision. Our labs are equipped to follow enantiomeric excess minute-by-minute.

Chiral analyticsChiral HPLC, GC, and CE methods are developed in parallel with route optimisation.
Kinetic insightIn-situ FTIR and reaction calorimetry reveal mechanistic behaviour before we scale.
Solid-state clarityPXRD and DSC confirm the stability of final crystalline forms, supporting registration filings.

Asymmetric catalysis

Homogeneous and heterogeneous catalysts deliver high ee with efficient recycle strategies for metals and ligands.

Smart resolutions

Classical resolution is re-imagined with custom resolving agents and continuous mother-liquor recovery.

Biocatalytic routes

When enzymes win, our fermentation colleagues deliver tailored biocatalysts with predictable supply.

Quality metrics tracked per campaign

Optical purityEnantiomeric excess trendlines captured with every batch and hold sample.
Impurity mappingDiastereomer tracking with acceptance criteria linked to filing commitments.
Catalyst lifecycleUsage, regeneration, and purge levels documented for cost-of-goods modelling.
Crystal formPolymorph fingerprints preserved to protect downstream formulation.
TECHNOLOGY PLATFORMS

Technology platforms for complex chemistry.

Choose the chemistry platform that fits your route, containment, stereochemistry, biology-enabled process, or digital collaboration needs.

Abstract connected technology platform network for complex chemistry
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Discuss Your Project

Tell us what you need to make, source, or scale. Our team will route your request to the right specialist.

Product sourcing
Custom synthesis
Scale-up support
info@dempochem.com
Westerstraat 10, 3016 DH, Rotterdam, Netherlands
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