Integrated Fermentation

Fermentation

Biology and chemistry under one roof.

Our fermentation suites cultivate, refine, and transfer biocatalysts seamlessly into synthetic routes, shortening the path from screening to scale.

Fermentation tailored to chemistry

We build bioprocesses with the downstream chemist in mind. Strains are screened for selectivity, productivity, and impurity profile, ensuring the broth integrates smoothly with synthetic steps or purification trains.

Co-located fermentation, purification, and chemical development teams shorten feedback loops dramatically. When a strain tweak changes impurity profile, the chemistry team receives samples in hours, not weeks.

Fermentation vessels operating in a clean manufacturing hall.

Strain discovery

Libraries of microbial and enzymatic variants give us a rapid start when looking for regio- or stereoselective activity.

Process intensification

Fed-batch, perfusion, and hybrid approaches are selected based on productivity and downstream compatibility.

Downstream mastery

Tangential flow filtration, adsorption, and crystallisation are co-designed with the chemists receiving the intermediates.

Quality & compliance

GMP documentation, environmental monitoring, and validation packages keep regulators confident from clinical through launch.

How a fermentation program unfolds

1. Ideation sprint
Define target activity, titres, and impurity guardrails with chemists and analysts in the room.
2. Lab evolution
Adaptive evolution and directed evolution campaigns run in parallel until productivity and selectivity meet brief.
3. Pilot realisation
200 L and 1,000 L skids generate data for scale-up, while downstream teams finalise purification design.
4. Commercial hand-off
Validation batches, documentation sets, and tech-transfer packs move to commercial GMP assets without drama.
TECHNOLOGY PLATFORMS

Technology platforms for complex chemistry.

Choose the chemistry platform that fits your route, containment, stereochemistry, biology-enabled process, or digital collaboration needs.

Abstract connected technology platform network for complex chemistry
Contact us

Discuss Your Project

Tell us what you need to make, source, or scale. Our team will route your request to the right specialist.

Product sourcing
Custom synthesis
Scale-up support
info@dempochem.com
Schedule a free consultation