Antitumor efficacy
Single-agent, combination, and reference-arm efficacy studies using project-matched PDX cohorts.
ONCOLOGY MODEL
Patient-Derived Xenograft (PDX) Models
PDX studies use patient-derived tumor tissue in immunodeficient mice for oncology efficacy, PK/PD, biomarker, and tissue-analysis work.
Tumor type, molecular context, cohort availability, host background, and study endpoints are aligned during technical review.
MODEL OVERVIEW
PDX models for translational oncology studies.
PDX models provide patient-derived tumor backgrounds for preclinical study design. Model selection is matched to the tumor context, compound mechanism, dosing strategy, and intended readouts.
Therapeutic areaOncology
SpeciesMouse
Model formatPatient-derived xenograft
Typical useEfficacy, PK/PD, Biomarkers
TYPICAL APPLICATIONS
What this model can support.
PK/PD integration
Exposure, target engagement, and efficacy correlation when PK/PD work is included in the protocol.
Biomarker strategy
Model selection and downstream readouts aligned to relevant molecular or pathological features.
Tissue analysis
Tumor and protocol-defined tissue collection for histology, IHC, molecular, or other downstream analysis.
COMMON READOUTS
Readouts selected around the study question.
Endpoints are finalized with the selected model, species or strain, treatment design, and partner laboratory before study placement.
Tumor response
Tumor volume, tumor growth inhibition, regression, and response duration where included in the study design.
Tolerability
Body weight, clinical observations, and dosing tolerance.
PK & exposure
Plasma, tumor, or selected tissue exposure where required.
PD & biomarkers
Target engagement, IHC, pathway, molecular, or other fit-for-purpose readouts.
Final model, cohort, host background, study design, endpoints, timelines, and deliverables are confirmed during technical review.
STUDY DESIGN
Key factors aligned before execution.
- Tumor type and histology
- Molecular profile and driver alterations
- Growth characteristics and cohort availability
- Host background and implantation site
- Compound mechanism and dosing strategy
- Required endpoints and tissue outputs
Discuss Your Program
Share the compound, mechanism, development question, preferred model, and intended endpoints. We can review fit, feasibility, and the appropriate partner-laboratory route for a PDX study.
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