HomeProductsBuilding BlocksOrganic Building BlocksAlicyclic HydrocarbonsRetaspimycin Hydrochloride
Chemical structure of CAS 857402-63-2

Retaspimycin Hydrochloride

CAS No.857402-63-2
MDL No.N/A
MFC31H46ClN3O8
MW624.20
InChI KeyOIRUWDYJGMHDHJ-AFXVCOSJSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
- -On RequestOn Request
Custom synthesis and bulk supply options are available upon request.

Product Information

Retaspimycin hydrochloride is the monohydrochloride salt of retaspimycin, a semi-synthetic, water-soluble analog of geldanamycin used in cancer treatment. It functions as an Hsp90 inhibitor and antineoplastic agent, containing retaspimycin(1+).

CAS No.857402-63-2
Product NameRetaspimycin Hydrochloride

Biological Targets

HSP90AA1·HSP90AB1

Associated Conditions

metastatic melanoma·non-small cell lung carcinoma·lung cancer·prostate carcinoma·breast carcinoma·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas.

Clinical cancer research : an official journal of the American Association for Cancer Research • Vol. 19, Issue 21 • 2013
PMID: 24045182PMC: PMC4330562DOI: 10.1158/1078-0432.CCR-13-0953

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Journal of medicinal chemistry • Vol. 49, Issue 15 • 2006
PMID: 16854066DOI: 10.1021/jm0603116

Effect of a single administration of testosterone on the immune response and lymphoid tissues in mice.

Cellular immunology • Vol. 20, Issue 2 • 1975
PMID: 1153DOI: 10.1016/0008-8749(75)90108-2

Documentation

Similar Products