HomeProductsBuilding BlocksFunctional GroupsEstersDimethyl Fumarate
Chemical structure of CAS 624-49-7

Dimethyl Fumarate

In Stock•Starting at $6 for 1 mg•Purity ≥ 99%
CAS No.624-49-7
MDL No.MFCD00064438
MFC6H8O4
MW144.12
InChI KeyLDCRTTXIJACKKU-ONEGZZNKSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg99%$6In Stock
25 g99%$6In Stock
4*25 g99%$25In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Dimethyl fumarate is an enoate ester formed by the condensation of both carboxy groups of fumaric acid with methanol. It is used in the treatment of adults with relapsing multiple sclerosis. It functions as an immunomodulator and antipsoriatic. It is a diester, an enoate ester, and a methyl ester, and is functionally related to methanol and fumaric acid.

CAS No.624-49-7
Product NameDimethyl Fumarate

Biological Targets

KEAP1

Associated Conditions

relapsing-remitting multiple sclerosis·multiple sclerosis·gliosarcoma·psoriatic arthritis·immune system disease·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Preventing Allograft Rejection by Targeting Immune Metabolism.

Cell reports • Vol. 13, Issue 4 • 2015
PMID: 26489460PMC: PMC4626381DOI: 10.1016/j.celrep.2015.09.036

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

Pharmacological research • Vol. 76 • 2013
PMID: 23942037DOI: 10.1016/j.phrs.2013.07.010

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

Brain : a journal of neurology • Vol. 134, Issue Pt 3 • 2011
PMID: 21354971DOI: 10.1093/brain/awq386

Dimethyl fumarate for multiple sclerosis.

Expert opinion on investigational drugs • Vol. 19, Issue 12 • 2010
PMID: 21067468DOI: 10.1517/13543784.2010.534778

Documentation

Similar Products