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Chemical structure of CAS 4434-05-3

Coumermycin A1

In Stock•Starting at $612 for 1 mg•Purity ≥ 99.4115%
CAS No.4434-05-3
MDL No.N/A
MFC55H59N5O20
MW1110.10
InChI KeyWTIJXIZOODAMJT-DHFGXMAYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg99.4115%$612In Stock
5 mg99.4115%$1751In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Coumermycin A1 is a hydroxycoumarin antibiotic derived from *Streptomyces rishiriensis*, exhibiting potent antibacterial and anticancer activity. It functions as a bacterial metabolite, DNA synthesis inhibitor, topoisomerase IV inhibitor, Hsp90 inhibitor, antineoplastic agent, and antimicrobial agent. It belongs to the classes of coumarins, glycosides, pyrroles, heteroarenecarboxylate esters, and aromatic amides.

CAS No.4434-05-3
Product NameCoumermycin A1
IrritantIrritant
Signal Word:Warning
HCode:H302
PCode:P264-P270-P301+P317-P330-P501

Related Articles

Studies related to this compound and its mechanism of action

Structural Basis for DNA Gyrase Interaction with Coumermycin A1.

Journal of medicinal chemistry • Vol. 62, Issue 8 • 2019
PMID: 30920824DOI: 10.1021/acs.jmedchem.8b01928

gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi.

Journal of bacteriology • Vol. 176, Issue 10 • 1994
PMID: 8188609PMC: PMC205466DOI: 10.1128/jb.176.10.3072-3075.1994

Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization.

Biochemistry • Vol. 15, Issue 17 • 1976
PMID: 782522DOI: 10.1021/bi00662a020

Documentation

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