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Chemical structure of CAS 158440-71-2

(-)-Irofulven

CAS No.158440-71-2
MDL No.MFCD00931906
MFC15H18O3
MW246.30
InChI KeyNICJCIQSJJKZAH-AWEZNQCLSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

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Product Information

Irofulven is a cyclohexenone.

CAS No.158440-71-2
Product Name(-)-Irofulven

Associated Conditions

breast cancer·prostate cancer·endometrial cancer·liver cancer·neoplasm·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Phase I study of irofulven (MGI 114), an acylfulvene illudin analog, in patients with acute leukemia.

Investigational new drugs • Vol. 19, Issue 1 • 2001
PMID: 11291829DOI: 10.1023/a:1006432012394

A phase II trial of 6-hydroxymethylacylfulvene (MGI-114, irofulven) in patients with advanced non-small cell cancer previously treated with chemotherapy.

Investigational new drugs • Vol. 19, Issue 1 • 2001
PMID: 11291837DOI: 10.1023/a:1006433528750

In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours.

European journal of cancer (Oxford, England : 1990) • Vol. 37, Issue 11 • 2001
PMID: 11435075DOI: 10.1016/s0959-8049(01)00135-6

Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.

Anticancer research • Vol. 21, Issue 3B • 2001
PMID: 11497260

Documentation

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