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Chemical structure of CAS 1193314-23-6

Cipargamin

CAS No.1193314-23-6
MDL No.N/A
MFC19H14Cl2FN3O
MW390.20
InChI KeyCKLPLPZSUQEDRT-WPCRTTGESA-N
CUSTOM SYNTHESIS

Pricing & Availability

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Product Information

CAS No.1193314-23-6
Product NameCipargamin

Associated Conditions

Plasmodium falciparum malaria·malaria
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.

Scientific reports • Vol. 6 • 2016
PMID: 27291296PMC: PMC4904242DOI: 10.1038/srep27806

Open-label, single-dose, parallel-group study in healthy volunteers to determine the drug-drug interaction potential between KAE609 (cipargamin) and piperaquine.

Antimicrobial agents and chemotherapy • Vol. 59, Issue 6 • 2015
PMID: 25845867PMC: PMC4432206DOI: 10.1128/AAC.00340-15

Spiroindolone KAE609 for falciparum and vivax malaria.

The New England journal of medicine • Vol. 371, Issue 5 • 2014
PMID: 25075833PMC: PMC4143746DOI: 10.1056/NEJMoa1315860

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.

Cell host & microbe • Vol. 13, Issue 2 • 2013
PMID: 23414762PMC: PMC3574224DOI: 10.1016/j.chom.2012.12.006

Documentation

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