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Chemical structure of CAS 11033-22-0

Coformycin

CAS No.11033-22-0
MDL No.N/A
MFC11H16N4O5
MW284.27
InChI KeyYOOVTUPUBVHMPG-LODYRLCVSA-N

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Product Information

Coformycin is an N-glycoside in which (8R)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol is linked to ribofuranose via a beta-N(3)-glycosidic bond. It is the parent compound of the coformycin class and functions as an EC 3.5.4.4 (adenosine deaminase) inhibitor. It is the conjugate base of coformycin(1+).

CAS No.11033-22-0
Product NameCoformycin

Biological Targets

ADA

Associated Conditions

leukemia
* The information provided here is compiled from public sources and is for reference only.

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Studies related to this compound and its mechanism of action

Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.

British journal of pharmacology • Vol. 140, Issue 6 • 2003
PMID: 14530217PMC: PMC1574113DOI: 10.1038/sj.bjp.0705523

Enantiospecific synthesis of carbapentostatins.

The Journal of organic chemistry • Vol. 68, Issue 1 • 2003
PMID: 12515468DOI: 10.1021/jo020612x

Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.

Journal of cellular biochemistry • Vol. 89, Issue 5 • 2003
PMID: 12874832DOI: 10.1002/jcb.10562

Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep.

Biochemical and biophysical research communications • Vol. 312, Issue 1 • 2003
PMID: 14630012DOI: 10.1016/j.bbrc.2003.09.220

Documentation

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