PF-00477736 is a diazepinoindole compound, specifically 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one. It features a 1-methylpyrazol-4-yl group at position 2 and a carboxamide formed by the condensation of the amino group at position 8 with the carboxy group of (2R)-2-cyclohexylglycine. It inhibits checkpoint kinase 1 (Chk1), acts as a non-specific serine/threonine protein kinase inhibitor, and serves as an antineoplastic agent. It is an amino acid amide, a pyrazole, and a diazepinoindole.
