PF-477736
| CAS No. | 952021-60-2 |
|---|---|
| MDL No. | N/A |
| MF | C22H25N7O2 |
| MW | 419.50 |
| InChI Key | NDEXUOWTGYUVGA-LJQANCHMSA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| - | - | On Request | On Request | |
| Custom synthesis and bulk supply options are available upon request. | ||||
Product Information
PF-00477736 is a diazepinoindole compound, specifically 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one. It features a 1-methylpyrazol-4-yl group at position 2 and a carboxamide formed by the condensation of the amino group at position 8 with the carboxy group of (2R)-2-cyclohexylglycine. It inhibits checkpoint kinase 1 (Chk1), acts as a non-specific serine/threonine protein kinase inhibitor, and serves as an antineoplastic agent. It is an amino acid amide, a pyrazole, and a diazepinoindole.
| CAS No. | 952021-60-2 |
|---|---|
| Product Name | PF-477736 |
| Heavy Atom Count | 31 | Rotatable Bond Count | 4 |
| Atom Stereo Count | 1 | Bond Stereo Count | 0 |
| HBA | 6 | HBD | 4 |
| TPSA | 130.190 Ų | Charge | 0 |
| Exact Mass | 419.20697 | Complexity | 1200.13 |
| pKa | 7.130 | XLogP | 2.492 |