HomeProductsBioactive CompoundsProtein Kinase Targetsc-Met/HGFRGlesatinib
Chemical structure of CAS 936694-12-1

Glesatinib

CAS No.936694-12-1
MDL No.N/A
MFC31H27F2N5O3S2
MW619.70
InChI KeyYRCHYHRCBXNYNU-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
- -On RequestOn Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.936694-12-1
Product NameGlesatinib

Biological Targets

MET·MST1R·TEK·FLT1·FLT4·

Associated Conditions

non-small cell lung carcinoma·cancer
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer.

Journal of medicinal chemistry • Vol. 60, Issue 17 • 2017
PMID: 28787156DOI: 10.1021/acs.jmedchem.7b00794

Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models.

Clinical cancer research : an official journal of the American Association for Cancer Research • Vol. 23, Issue 21 • 2017
PMID: 28765324DOI: 10.1158/1078-0432.CCR-17-1192

Targeting the Met pathway in lung cancer.

Expert review of anticancer therapy • Vol. 12, Issue 4 • 2012
PMID: 22500688DOI: 10.1586/era.12.16

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.

Bioorganic & medicinal chemistry letters • Vol. 18, Issue 9 • 2008
PMID: 18434145DOI: 10.1016/j.bmcl.2008.04.009

Documentation

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