HomeProductsBioactive CompoundsJAK/STAT SignalingJAKCAS 935666-88-9
Chemical structure of CAS 935666-88-9

5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

CAS No.935666-88-9
MDL No.N/A
MFC14H14ClFN8
MW348.76
InChI KeyPDOQBOJDRPLBQU-QMMMGPOBSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
- -On RequestOn Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.935666-88-9
Product Name5-chloro-2-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-4-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Biological Targets

JAK2

Associated Conditions

gastric cancer·essential thrombocythemia·non-small cell lung carcinoma·primary myelofibrosis·cancer·
* The information provided here is compiled from public sources and is for reference only.

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

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Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2.

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