| CAS No. | 917879-39-1 |
|---|---|
| MDL No. | MFCD11977739 |
| MF | C24H25N5O5S |
| MW | 495.60 |
| InChI Key | JGEBLDKNWBUGRZ-HXUWFJFHSA-N |
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 1 mg | 98% | $94 | In Stock | |
| 5 mg | 98% | $291 | In Stock | |
| 10 mg | 99.53% ; | $468 | In Stock | |
| 25 mg | 99.53% ; | $820 | In Stock | |
| 50 mg | 99.53% ; | $1276 | In Stock | |
| 100 mg | 99.53% ; | $1782 | In Stock | |
| 200 mg | 99.53% ; | $2403 | In Stock | |
| Custom synthesis and bulk supply options are available upon request. | ||||
MK-2461 is a benzocycloheptapyridine, specifically 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one, substituted at positions 3 and 7 with 1-methyl-1H-pyrazol-4-yl and [{[(2R)-1,4-dioxan-2-yl]methyl}(methyl)sulfamoyl]amino groups, respectively. It is a novel ATP-competitive, multi-targeted inhibitor of activated c-Met with an IC50 of 2.5 nM. It functions as an antineoplastic agent, c-Met tyrosine kinase inhibitor, and apoptosis inducer. It belongs to the classes of pyrazoles, benzocycloheptapyridines, dioxanes, and sulfamides.
| CAS No. | 917879-39-1 |
|---|---|
| Product Name | Mk-2461 |
| Heavy Atom Count | 35 | Rotatable Bond Count | 6 |
| Atom Stereo Count | 1 | Bond Stereo Count | 0 |
| HBA | 8 | HBD | 1 |
| TPSA | 115.650 Ų | Charge | 0 |
| Exact Mass | 495.15764 | Complexity | 1564.17 |
| pKa | 5.875 | XLogP | 2.153 |