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Chemical structure of CAS 912444-00-9

Veliparib

CAS No.912444-00-9
MDL No.MFCD16661059
MFC13H16N4O
MW244.29
InChI KeyJNAHVYVRKWKWKQ-CYBMUJFWSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
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Custom synthesis and bulk supply options are available upon request.

Product Information

Veliparib is a benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor and functions as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor.

CAS No.912444-00-9
Product NameVeliparib

Biological Targets

PARP1·PARP3·PARP2

Associated Conditions

metastatic melanoma·pancreatic carcinoma·prostate cancer·malignant glioma·ovarian cancer·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences • Vol. 872, Issue 1-2 • 2008
PMID: 18692448PMC: PMC2634284DOI: 10.1016/j.jchromb.2008.07.032

An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitors.

Analytical biochemistry • Vol. 381, Issue 2 • 2008
PMID: 18674509DOI: 10.1016/j.ab.2008.07.007

A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology • Vol. 88, Issue 2 • 2008
PMID: 18456354DOI: 10.1016/j.radonc.2008.04.005

Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage.

Cancer biology & therapy • Vol. 7, Issue 6 • 2008
PMID: 18376143DOI: 10.4161/cbt.7.6.5933

Documentation

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