Pevonedistat
| CAS No. | 905579-51-3 |
|---|---|
| MDL No. | MFCD17215201 |
| MF | C21H25N5O4S |
| MW | 443.50 |
| InChI Key | MPUQHZXIXSTTDU-QXGSTGNESA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| - | - | On Request | On Request | |
| Custom synthesis and bulk supply options are available upon request. | ||||
Product Information
Pevonedistat is a pyrrolopyrimidine, specifically a 7H-pyrrolo[2,3-d]pyrimidine substituted at position 4 with a (1S)-2,3-dihydro-1H-inden-1-ylnitrilo group and at position 7 with a (1S,3S,4S)-3-hydroxy-4-[(sulfamoyloxy)methyl]cyclopentyl group. It is a potent and selective NEDD8-activating enzyme inhibitor with an IC50 of 4.7 nM, currently under clinical investigation for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes. It functions as an apoptosis inducer and antineoplastic agent. It is also a secondary amino compound, a member of cyclopentanols, a sulfamidate, and a member of indanes.
| CAS No. | 905579-51-3 |
|---|---|
| Product Name | Pevonedistat |
Biological Targets
UBA3·NAE1
Associated Conditions
myelodysplastic syndrome·leukemia·diffuse large B-cell lymphoma·hepatocellular carcinoma·acute lymphoblastic leukemia·
* The information provided here is compiled from public sources and is for reference only.
