BGJ-398 is a phenylurea in which a hydrogen on one nitrogen is replaced by a 2,6-dichloro-3,5-dimethoxyphenyl group, and the other nitrogen is substituted with a methyl group and a 6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl group. It is a potent and selective fibroblast growth factor receptor inhibitor, functioning as a fibroblast growth factor receptor antagonist and an antineoplastic agent. It belongs to the classes of aminopyrimidine, N-arylpiperazine, N-alkylpiperazine, dichlorobenzene, and phenylureas.
