Foretinib is a quinoline substituted at positions 4, 6, and 7 with 2-fluoro-4-[({1-[(4-fluorophenyl)carbamoyl]cyclopropyl}carbonyl)amino]phenoxy, methoxy, and 3-(morpholin-4-yl)propoxy groups, respectively. It is a multi-kinase inhibitor with activity as a c-Met tyrosine kinase inhibitor, vascular endothelial growth factor receptor antagonist, antineoplastic agent, and apoptosis inducer. It belongs to the classes of aromatic ethers, morpholines, quinolines, monofluorobenzenes, cyclopropanes, and dicarboxylic acid diamides.
