Cilastatin
In Stock•Starting at $52 for 250 mg•Purity ≥ 95%
| CAS No. | 82009-34-5 |
|---|---|
| MDL No. | MFCD00867379 |
| MF | C16H26N2O5S |
| MW | 358.50 |
| InChI Key | DHSUYTOATWAVLW-WFVMDLQDSA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 250 mg | 95% | $52 | In Stock | |
| 1 g | 95% | $119 | In Stock | |
| 5 g | 95% | $411 | In Stock | |
| 10 g | 95% | $701 | In Stock | |
| 25 g | 95% | $1400 | In Stock |
Product Information
Cilastatin is the thioether formed by the oxidative coupling of the thiol group of L-cysteine with the 7-position of (2Z)-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid. It inhibits dehydropeptidase I (EC 3.4.13.19), an enzyme in the brush border of renal tubes that degrades imipenem. Administered as the sodium salt with imipenem, it prolongs its antibacterial effect by preventing renal metabolism to inactive and nephrotoxic products. Cilastatin also inhibits leukotriene D4 dipeptidase, preventing the conversion of leukotriene D4 to leukotriene E4. It functions as a protease inhibitor, xenobiotic, environmental contaminant, and non-proteinogenic L-alpha-amino acid, being a L-cysteine derivative, organic sulfide, and carboxamide. It is the conjugate acid of cilastatin(1-).
| CAS No. | 82009-34-5 |
|---|---|
| Product Name | Cilastatin |
Biological Targets
DPEP1
Associated Conditions
Sepsis·infection·urinary tract infection·pneumonia·pyelonephritis·
* The information provided here is compiled from public sources and is for reference only.