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Chemical structure of CAS 76721-89-6

Thiorphan

In Stock•Starting at $92 for 25 mg•Purity ≥ 98%
CAS No.76721-89-6
MDL No.MFCD00058435
MFC12H15NO3S
MW253.32
InChI KeyLJJKNPQAGWVLDQ-UHFFFAOYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
25 mg98%$92In Stock
50 mg98%$155In Stock
100 mg98%$188In Stock
250 mg98%$389In Stock
1 g98%$1055In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Thiorphan is an N-acyl-amino acid.

CAS No.76721-89-6
Product NameThiorphan
Heavy Atom Count17Rotatable Bond Count6
Atom Stereo Count1Bond Stereo Count0
HBA3HBD3
TPSA66.400 ŲCharge0
Exact Mass253.07726Complexity380.60
pKa3.413XLogP0.976

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Studies related to this compound and its mechanism of action

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.

Hypertension (Dallas, Tex. : 1979) • Vol. 75, Issue 1 • 2020
PMID: 31786979PMC: PMC7286421DOI: 10.1161/HYPERTENSIONAHA.119.14071

Neutral endopeptidase (NEP) inhibitors - thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro.

Chemico-biological interactions • Vol. 307 • 2019
PMID: 31054283DOI: 10.1016/j.cbi.2019.04.033

Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.

Scientific reports • Vol. 6 • 2016
PMID: 27649628PMC: PMC5030486DOI: 10.1038/srep33678

Role of mu- and delta-opioid receptors in the nucleus accumbens in cocaine-seeking behavior.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology • Vol. 34, Issue 8 • 2009
PMID: 19279569PMC: PMC2706587DOI: 10.1038/npp.2009.28

Documentation

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