Fludarabine Phosphate
In Stock•Starting at $8 for 1 mg•Purity ≥ 98%
| CAS No. | 75607-67-9 |
|---|---|
| MDL No. | MFCD00866418 |
| MF | C10H13FN5O7P |
| MW | 365.21 |
| InChI Key | GIUYCYHIANZCFB-FJFJXFQQSA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 1 mg | 98% | $8 | In Stock | |
| 10 mg | 98% | $9 | In Stock | |
| 50 mg | 98% | $15 | In Stock | |
| 100 mg | 98% | $18 | In Stock | |
| 250 mg | 98% | $26 | In Stock |
Product Information
Fludarabine phosphate is a purine arabinonucleoside monophosphate with 2-fluoroadenine as its nucleobase. As a prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A, which is then phosphorylated intracellularly by deoxycytidine kinase to form the active triphosphate, 2-fluoro-ara-ATP. This compound functions as a DNA chain terminator once incorporated into DNA. It is used to treat adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent-containing regimen. It acts as an antimetabolite, antineoplastic agent, immunosuppressive agent, antiviral agent, prodrug, and DNA synthesis inhibitor. It is also an organofluorine compound, a nucleoside analogue, and a purine arabinonucleoside monophosphate, and is functionally related to 2-fluoroadenine.
| CAS No. | 75607-67-9 |
|---|---|
| Product Name | Fludarabine Phosphate |
Biological Targets
POLA1·POLD4·POLD3·POLD1·POLD2·
Associated Conditions
adult T-cell leukemia/lymphoma·acute monocytic leukemia·Sezary's disease·melanoma·Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive·
* The information provided here is compiled from public sources and is for reference only.
