BI-2536 is a 7,8-dihydropteridin-6(5H)-one tetrahydropterin substituted at positions 2, 5, 7R, and 8 with 2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenylamino, methyl, ethyl, and cyclopentyl groups, respectively. It is a PLK1 inhibitor with antineoplastic activity, acting as an EC 2.7.11.21 polo kinase inhibitor, antineoplastic agent, and apoptosis inducer. It belongs to cyclopentanes, tetrahydropterins, monomethoxybenzenes, substituted anilines, benzamides, secondary carboxamides, piperidines, secondary amino compounds, and tertiary amino compounds.
