Mechanism of inactivation of γ-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115).
Journal of the American Chemical Society • Vol. 137, Issue 7 • 2015
CPP-115, a vigabatrin analogue, decreases spasms in the multiple-hit rat model of infantile spasms.
Epilepsia • Vol. 55, Issue 1 • 2014
The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.
Journal of medicinal chemistry • Vol. 55, Issue 2 • 2012
(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction.
Journal of medicinal chemistry • Vol. 55, Issue 1 • 2012