2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile
In Stock•Starting at $17 for 1 mg•Purity ≥ 98%
| CAS No. | 612487-72-6 |
|---|---|
| MDL No. | N/A |
| MF | C19H18N4O2 |
| MW | 334.40 |
| InChI Key | BLTVBQXJFVRPFK-UHFFFAOYSA-N |
Pricing & Availability
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 1 mg | 98+% | $17 | In Stock | |
| 2 mg | 98+% | $24 | In Stock | |
| 5 mg | 98+% | $28 | In Stock | |
| 10 mg | 98+% | $34 | In Stock | |
| Custom synthesis and bulk supply options are available upon request. | ||||
Product Information
AZD1080 is a hydroxyindole with substituents at positions 2, 3, and 5: hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups, respectively. It is a potent, brain-permeable inhibitor of human GSK3α and GSK3β with Ki values of 6.9 nM and 31 nM. Developed by AstraZeneca for Alzheimer's disease (clinical trials discontinued), it acts as an EC 2.7.11.26 (tau-protein kinase) inhibitor, tau aggregation inhibitor, antineoplastic agent, and apoptosis inducer. It belongs to morpholines, pyridines, hydroxyindoles, nitriles, and tertiary amino compounds.
| CAS No. | 612487-72-6 |
|---|---|
| Product Name | 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile |
Biological Targets
GSK3A·GSK3B
* The information provided here is compiled from public sources and is for reference only.
