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Chemical structure of CAS 6104-71-8

N-Desmethylclozapine

CAS No.6104-71-8
MDL No.MFCD00210189
MFC17H17ClN4
MW312.80
InChI KeyJNNOSTQEZICQQP-UHFFFAOYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
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Custom synthesis and bulk supply options are available upon request.

Product Information

N-desmethylclozapine is a dibenzodiazepine substituted with chloro and piperazino groups, a major metabolite of clozapine. It is a potent and selective 5-HT2C serotonin receptor antagonist, as well as a delta-opioid receptor agonist and serotonergic antagonist. It functions as a metabolite, piperazine, and organochlorine compound.

CAS No.6104-71-8
Product NameN-Desmethylclozapine

Associated Conditions

schizophrenia·schizoaffective disorder
* The information provided here is compiled from public sources and is for reference only.

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Studies related to this compound and its mechanism of action

Induction of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake.

Pharmacology, biochemistry, and behavior • Vol. 75, Issue 2 • 2003
PMID: 12873613DOI: 10.1016/s0091-3057(03)00079-0

Central effects of clozapine in regulating micturition in anesthetized rats.

BMC pharmacology • Vol. 2 • 2002
PMID: 11884246PMC: PMC100786DOI: 10.1186/1471-2210-2-6

Discovery of an ectopic activation site on the M(1) muscarinic receptor.

Molecular pharmacology • Vol. 61, Issue 6 • 2002
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Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine.

Journal of child and adolescent psychopharmacology • Vol. 12, Issue 2 • 2002
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Documentation

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