Proglumetacin is a carboxylic ester formed by the formal condensation of the carboxy group of indometacin with the hydroxy group of 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate. It is used as its dimaleate salt to control pain and inflammation in musculoskeletal and joint disorders. After oral administration, it is metabolized into indometacin and proglumide, which has antisecretory effects that protect the stomach lining. Proglumetacin functions as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a lipoxygenase inhibitor, an inhibitor of prostaglandin-endoperoxide synthase (EC 1.14.99.1), an antipyretic, and a prodrug. It is classified as an N-acylindole, an aromatic ether, a carboxylic ester, an N-alkylpiperazine, a benzamide, and a monochlorobenzenes. It is functionally related to indometacin and proglumide.
