HomeProductsBioactive CompoundsDNA Damage & RepairTopoisomeraseAmsacrine
Chemical structure of CAS 51264-14-3

Amsacrine

In Stock•Starting at $57 for 10 mg•Purity ≥ 98%
CAS No.51264-14-3
MDL No.MFCD00242748
MFC21H19N3O3S
MW393.50
InChI KeyXCPGHVQEEXUHNC-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
10 mg98%$57In Stock
25 mg98%$108In Stock
50 mg98%$144In Stock
100 mg98%$257In Stock
250 mg98%$511In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Amsacrine is a sulfonamide with a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity and functions as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor. It is classified as an antineoplastic agent, a sulfonamide, an acridine, and an aromatic ether.

CAS No.51264-14-3
Product NameAmsacrine

Biological Targets

TOP2A·TOP2B

Associated Conditions

acute myeloid leukemia·neoplasm·leukemia·myelodysplastic syndrome
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Atp-bound topoisomerase ii as a target for antitumor drugs.

The Journal of biological chemistry • Vol. 276, Issue 19 • 2001
PMID: 11278845DOI: 10.1074/jbc.M011143200

Analysis of cleavage complexes using reactive inhibitor derivatives.

Methods in molecular biology (Clifton, N.J.) • Vol. 95 • 2001
PMID: 11089223DOI: 10.1385/1-59259-057-8:89

Cell-cycle analysis of drug-treated cells.

Methods in molecular biology (Clifton, N.J.) • Vol. 95 • 2001
PMID: 11089235DOI: 10.1385/1-59259-057-8:229

Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.

Cytometry • Vol. 43, Issue 3 • 2001
PMID: 11170102

Documentation

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