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Chemical structure of CAS 475205-49-3

A-317491

CAS No.475205-49-3
MDL No.MFCD28044314
MFC33H27NO8
MW565.60
InChI KeyVQGBOYBIENNKMI-LJAQVGFWSA-N
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Product Information

CAS No.475205-49-3
Product NameA-317491
Heavy Atom Count42Rotatable Bond Count9
Atom Stereo Count1Bond Stereo Count0
HBA5HBD3
TPSA141.440 ŲCharge0
Exact Mass565.17367Complexity1680.97
pKa2.075XLogP6.294

Related Articles

Studies related to this compound and its mechanism of action

Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice.

European journal of pharmacology • Vol. 688, Issue 1-3 • 2012
PMID: 22634164DOI: 10.1016/j.ejphar.2012.05.008

P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase 1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.

The European journal of neuroscience • Vol. 33, Issue 12 • 2011
PMID: 21453436DOI: 10.1111/j.1460-9568.2011.07667.x

Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.

Neuroscience letters • Vol. 465, Issue 3 • 2009
PMID: 19765404DOI: 10.1016/j.neulet.2009.09.015

Roles of peripheral P2X and P2Y receptors in the development of melittin-induced nociception and hypersensitivity.

Neurochemical research • Vol. 33, Issue 10 • 2008
PMID: 18404374DOI: 10.1007/s11064-008-9689-6

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