Tramadol Hydrochloride

(R,R)-Tramadol hydrochloride is the hydrochloride salt formed by reacting (R,R)-tramadol with one equivalent of hydrogen chloride. It is the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, exhibiting ten-fold higher analgesic potency than the (S,S)-enantiomer. It acts as a delta-, kappa-, and mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, an NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, and a serotonin uptake inhibitor. It contains (R,R)-tramadol(1+) and is the enantiomer of (S,S)-tramadol hydrochloride.