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Chemical structure of CAS 34273-04-6

Guanosine 5'-(Beta,Gamma-Imido)Triphosphate

CAS No.34273-04-6
MDL No.N/A
MFC10H17N6O13P3
MW522.20
InChI KeyUQABYHGXWYXDTK-UUOKFMHZSA-N
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Product Information

Guanosine 5'-[beta,gamma-imido]triphosphate is a nucleoside triphosphate analog of GTP, where the oxygen atom bridging the beta- and gamma-phosphates is replaced by a nitrogen atom. It is a non-hydrolyzable GTP analog that tightly binds to G-proteins in the presence of Mg(2+). It is the conjugate acid of guanosine 5'-[beta,gamma-imido]triphosphate(4-).

CAS No.34273-04-6
Product NameGuanosine 5'-(Beta,Gamma-Imido)Triphosphate
Heavy Atom Count32Rotatable Bond Count8
Atom Stereo Count6Bond Stereo Count0
HBA13HBD9
TPSA301.900 ŲCharge0
Exact Mass522.00664Complexity1208.76
pKa4.180XLogP-2.763

Related Articles

Studies related to this compound and its mechanism of action

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.

Nature communications • Vol. 12, Issue 1 • 2021
PMID: 34344863PMC: PMC8333338DOI: 10.1038/s41467-021-24878-z

Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.

Chemico-biological interactions • Vol. 234 • 2015
PMID: 25526675DOI: 10.1016/j.cbi.2014.12.013

Zinc oxide nanoparticle disruption of store-operated calcium entry in a muscarinic receptor signaling pathway.

Toxicology in vitro : an international journal published in association with BIBRA • Vol. 24, Issue 7 • 2010
PMID: 20708676DOI: 10.1016/j.tiv.2010.08.005

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.

The EMBO journal • Vol. 22, Issue 5 • 2003
PMID: 12606577PMC: PMC150343DOI: 10.1093/emboj/cdg110

Documentation

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