HomeProductsBioactive CompoundsTransporters & Ion ChannelsCFTRElexacaftor
Chemical structure of CAS 2216712-66-0

Elexacaftor

In Stock•Starting at $24 for 1 mg•Purity ≥ 99%
CAS No.2216712-66-0
MDL No.N/A
MFC26H34F3N7O4S
MW597.70
InChI KeyMVRHVFSOIWFBTE-INIZCTEOSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg99%$24In Stock
2 mg99%$35In Stock
5 mg99%$56In Stock
10 mg99%$85In Stock
25 mg99%$150In Stock
50 mg99%$242In Stock
100 mg99%$410In Stock
250 mg99%$693In Stock
1 g99%$1866In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Elexacaftor is a small molecule CFTR corrector used in combination with tezacaftor and ivacaftor to treat cystic fibrosis in patients with one F508del-CFTR mutation.

CAS No.2216712-66-0
Product NameElexacaftor

Biological Targets

CFTR

Associated Conditions

cystic fibrosis
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Elexacaftor co-potentiates the activity of F508del and gating mutants of CFTR.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society • Vol. 20, Issue 5 • 2021
PMID: 33775603PMC: PMC8463622DOI: 10.1016/j.jcf.2021.03.011

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

JCI insight • Vol. 5, Issue 18 • 2020
PMID: 32853178PMC: PMC7526550DOI: 10.1172/jci.insight.139983

Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.

Lancet (London, England) • Vol. 394, Issue 10212 • 2019
PMID: 31679946PMC: PMC7571408DOI: 10.1016/S0140-6736(19)32597-8

Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two alleles.

ERJ open research • Vol. 5, Issue 2 • 2019
PMID: 31218221PMC: PMC6571452DOI: 10.1183/23120541.00082-2019

Documentation

Similar Products