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Chemical structure of CAS 2169299-67-4

TGF-|ARI inhibitor 1

CAS No.2169299-67-4
MDL No.N/A
MFC21H19N7O
MW385.40
InChI KeyFSQGWBXWGNWEAV-CMDGGOBGSA-N
CUSTOM SYNTHESIS

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
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Product Information

CAS No.2169299-67-4
Product NameTGF-|ARI inhibitor 1
Heavy Atom Count29Rotatable Bond Count4
Atom Stereo Count0Bond Stereo Count1
HBA7HBD1
TPSA103.990 ŲCharge0
Exact Mass385.16511Complexity1281.67
pKa7.130XLogP2.408

Related Articles

Studies related to this compound and its mechanism of action

Discovery of a Selective, Novel TGF-βR1 Inhibitor GFH018 for the Treatment of Solid Tumors.

Journal of medicinal chemistry • Vol. 68, Issue 12 • 2025
PMID: 40505138DOI: 10.1021/acs.jmedchem.5c00121

First-in-human study of GFH018, a small molecule inhibitor of transforming growth factor-β receptor I inhibitor, in patients with advanced solid tumors.

BMC cancer • Vol. 24, Issue 1 • 2024
PMID: 38600507PMC: PMC11007962DOI: 10.1186/s12885-024-12216-7

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Immunology • Vol. 160, Issue 1 • 2020
PMID: 32020584PMC: PMC7160657DOI: 10.1111/imm.13175

Documentation

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