| CAS No. | 209984-57-6 |
|---|---|
| MDL No. | MFCD09832551 |
| MF | C26H23F2N3O4 |
| MW | 479.50 |
| InChI Key | ULSSJYNJIZWPSB-CVRXJBIPSA-N |
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 1 mg | 98% | $49 | In Stock | |
| 5 mg | 98% | $77 | In Stock | |
| 10 mg | 98% | $93 | In Stock | |
| 25 mg | 98% | $111 | In Stock |
LY-411575 is a dibenzoazepine, specifically 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one, substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N(2)-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell-permeable, and selective gamma-secretase inhibitor with EC 3.4.23.46 (memapsin 2) inhibitory activity. It has been tested as a potential treatment for Alzheimer's disease and shows promise for mitigating severe hearing loss. It is also classified as a difluorobenzene, a lactam, and a secondary alcohol.
| CAS No. | 209984-57-6 |
|---|---|
| Product Name | (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide |
| Heavy Atom Count | 35 | Rotatable Bond Count | 5 |
| Atom Stereo Count | 3 | Bond Stereo Count | 0 |
| HBA | 4 | HBD | 3 |
| TPSA | 98.740 Ų | Charge | 0 |
| Exact Mass | 479.16566 | Complexity | 1293.01 |
| pKa | 7.130 | XLogP | 3.004 |
| 50 mg | 98% | $186 | In Stock |
| 100 mg | 98% | $312 | In Stock |
| 250 mg | 98% | $591 | In Stock |
| Custom synthesis and bulk supply options are available upon request. |
