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Chemical structure of CAS 1844849-10-0

Pf-06821497

CAS No.1844849-10-0
MDL No.N/A
MFC22H24Cl2N2O5
MW467.30
InChI KeyRXCVUHMIWHRLDF-HXUWFJFHSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

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Product Information

CAS No.1844849-10-0
Product NamePf-06821497

Associated Conditions

neoplasm
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).

Journal of medicinal chemistry • Vol. 61, Issue 3 • 2018
PMID: 29211475DOI: 10.1021/acs.jmedchem.7b01375

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Blood • Vol. 117, Issue 8 • 2011
PMID: 21190999PMC: PMC3062411DOI: 10.1182/blood-2010-11-321208

Documentation