Remdesivir

Remdesivir is a carboxylic ester formed by the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. It is a broad-spectrum antiviral prodrug with potent in vitro antiviral activity against RNA viruses including Ebola virus, MERS-CoV, and SARS-CoV. Currently in Phase III clinical trials for adult Covid-19 treatment. It functions as an antiviral drug, prodrug, and anticoronaviral agent. It is a carboxylic ester, pyrrolotriazine, nitrile, phosphoramidate ester, C-nucleoside, and aromatic amine. It is functionally related to GS-441524.