| CAS No. | 1799633-27-4 |
|---|---|
| MDL No. | N/A |
| MF | C39H37ClF4N6O6S |
| MW | 829.30 |
| InChI Key | ZFBHXVOCZBPADE-SSEXGKCCSA-N |
| Pack Size | Purity | Price | Availability | Action |
|---|---|---|---|---|
| 1 mg | 98% | $108 | In Stock | |
| 5 mg | 98% | $289 | In Stock | |
| 10 mg | 98% | $459 | In Stock | |
| 25 mg | 98% | $949 | In Stock | |
| 50 mg | 98% | $1292 | In Stock | |
| 100 mg | 98% | $2192 | In Stock | |
| Custom synthesis and bulk supply options are available upon request. | ||||
S63845 is a potent and selective MCL1 inhibitor with a Kd of 0.19 nM for human MCL1. It is a small molecule that selectively binds to the BH3-binding groove of MCL1, inducing apoptosis in MCL1-dependent cancer cells, including multiple myeloma, leukemia, and lymphoma, via the BAX/BAK-dependent mitochondrial pathway.
| CAS No. | 1799633-27-4 |
|---|---|
| Product Name | (2~{r})-2-[5-[3-Chloranyl-2-Methyl-4-[2-(4-Methylpiperazin-1-Yl)ethoxy]phenyl]-6-(5-Fluoranylfuran-2-Yl)thieno[2,3-D]pyrimidin-4-Yl]oxy-3-[2-[[2-[2,2,2-Tris(Fluoranyl)ethyl]pyrazol-3-Yl]methoxy]phenyl]propanoic Acid |
| Heavy Atom Count | 57 | Rotatable Bond Count | 15 |
| Atom Stereo Count | 1 | Bond Stereo Count | 0 |
| HBA | 12 | HBD | 1 |
| TPSA | 128.210 Ų | Charge | 0 |
| Exact Mass | 828.21199 | Complexity | 2359.14 |
| pKa | 0.577 | XLogP | 7.758 |
