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Chemical structure of CAS 1654725-02-6

Glpg-1837

CAS No.1654725-02-6
MDL No.N/A
MFC16H20N4O3S
MW348.40
InChI KeyGHTGYZMBQPXTCQ-UHFFFAOYSA-N

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Product Information

CAS No.1654725-02-6
Product NameGlpg-1837
Heavy Atom Count24Rotatable Bond Count3
Atom Stereo Count0Bond Stereo Count0
HBA5HBD3
TPSA110.100 ŲCharge0
Exact Mass348.12561Complexity805.65
pKa7.130XLogP2.409

Related Articles

Studies related to this compound and its mechanism of action

In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators.

International journal of molecular sciences • Vol. 23, Issue 18 • 2022
PMID: 36142670PMC: PMC9502978DOI: 10.3390/ijms231810758

GLPG1837, a CFTR potentiator, in p.Gly551Asp (G551D)-CF patients: An open-label, single-arm, phase 2a study (SAPHIRA1).

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society • Vol. 18, Issue 5 • 2019
PMID: 31147302DOI: 10.1016/j.jcf.2019.05.006

Structural identification of a hotspot on CFTR for potentiation.

Science (New York, N.Y.) • Vol. 364, Issue 6446 • 2019
PMID: 31221859PMC: PMC7184887DOI: 10.1126/science.aaw7611

Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent.

Journal of medicinal chemistry • Vol. 61, Issue 4 • 2018
PMID: 29148763DOI: 10.1021/acs.jmedchem.7b01288

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