HomeProductsBioactive CompoundsProtein Kinase TargetsBTKBms-986142
Chemical structure of CAS 1643368-58-4

Bms-986142

CAS No.1643368-58-4
MDL No.N/A
MFC32H30F2N4O4
MW572.60
InChI KeyZRYMMWAJAFUANM-INIZCTEOSA-N

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Product Information

CAS No.1643368-58-4
Product NameBms-986142

Biological Targets

BTK

Associated Conditions

rheumatoid arthritis·osteoarthritis
* The information provided here is compiled from public sources and is for reference only.

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Studies related to this compound and its mechanism of action

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Immunology • Vol. 160, Issue 1 • 2020
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Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.

PloS one • Vol. 12, Issue 7 • 2017
PMID: 28742141PMC: PMC5524405DOI: 10.1371/journal.pone.0181782

Safety, pharmacokinetics, and pharmacodynamics of BMS-986142, a novel reversible BTK inhibitor, in healthy participants.

European journal of clinical pharmacology • Vol. 73, Issue 6 • 2017
PMID: 28265691PMC: PMC5423977DOI: 10.1007/s00228-017-2226-2

Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.

Journal of medicinal chemistry • Vol. 59, Issue 19 • 2016
PMID: 27583770DOI: 10.1021/acs.jmedchem.6b01088

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