Product Information

CAS No.	1629677-75-3
Product Name	Zetomipzomib

Associated Conditions

Anemia, Hemolytic, Autoimmune·type II hypersensitivity reaction disease·polymyositis·inflammation·lupus nephritis·

* The information provided here is compiled from public sources and is for reference only.

Studies related to this compound and its mechanism of action

Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome.

Drug metabolism and disposition: the biological fate of chemicals • Vol. 49, Issue 9 • 2021

PMID: 34234005 DOI: 10.1124/dmd.120.000307

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Immunology • Vol. 160, Issue 1 • 2020

PMID: 32020584 PMC: PMC7160657 DOI: 10.1111/imm.13175

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Journal of medicinal chemistry • Vol. 61, Issue 24 • 2018

PMID: 30380863 DOI: 10.1021/acs.jmedchem.8b01201

Interaction of 1,N6-ethenoadenine derivatives of triphosphopyridine and reduced triphosphopyridine nucleotides with dihydrofolate reductase from amethopterin-resistant L1210 cells.

Biochemistry • Vol. 15, Issue 18 • 1976

PMID: 9129 DOI: 10.1021/bi00663a019

Zetomipzomib

CAS No.	1629677-75-3
MDL No.	N/A
MF	C₃₀H₄₂N₄O₈
MW	586.70
InChI Key	GHYOCDFICYLMRF-UTIIJYGPSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

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Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	1629677-75-3
Product Name	Zetomipzomib

Associated Conditions

Anemia, Hemolytic, Autoimmune·type II hypersensitivity reaction disease·polymyositis·inflammation·lupus nephritis·

* The information provided here is compiled from public sources and is for reference only.

Zetomipzomib

Pricing & Availability

Product Information

Biological Profile

Properties

Associated Conditions

Zetomipzomib

Pricing & Availability

Product Information

Biological Profile

Properties

Associated Conditions

Documentation

Zetomipzomib

Pricing & Availability

Product Information

Biological Profile

Properties

Associated Conditions

Related Articles

Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome.

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Interaction of 1,N6-ethenoadenine derivatives of triphosphopyridine and reduced triphosphopyridine nucleotides with dihydrofolate reductase from amethopterin-resistant L1210 cells.

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Carfilzomib

Zetomipzomib

Pricing & Availability

Product Information

Biological Profile

Properties

Associated Conditions

Related Articles

Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome.

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Interaction of 1,N6-ethenoadenine derivatives of triphosphopyridine and reduced triphosphopyridine nucleotides with dihydrofolate reductase from amethopterin-resistant L1210 cells.

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Carfilzomib

Documentation