Product Information

CAS No.	1508250-71-2
Product Name	Nazartinib

Biological Targets

EGFR

Associated Conditions

neoplasm·lung cancer·bronchial neoplasm·non-small cell lung carcinoma

* The information provided here is compiled from public sources and is for reference only.

Studies related to this compound and its mechanism of action

Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy.

Cancer science • Vol. 107, Issue 9 • 2016

PMID: 27323238 PMC: PMC5021039 DOI: 10.1111/cas.12996

Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers.

Journal of medicinal chemistry • Vol. 59, Issue 14 • 2016

PMID: 27433829 DOI: 10.1021/acs.jmedchem.5b01985

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.

Journal of medicinal chemistry • Vol. 59, Issue 14 • 2016

PMID: 26882288 DOI: 10.1021/acs.jmedchem.5b00840

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.

Cancer research • Vol. 76, Issue 6 • 2016

PMID: 26825170 DOI: 10.1158/0008-5472.CAN-15-2581

Nazartinib

CAS No.	1508250-71-2
MDL No.	MFCD28963918
MF	C₂₆H₃₁ClN₆O₂
MW	495.00
InChI Key	IOMMMLWIABWRKL-WUTDNEBXSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	1508250-71-2
Product Name	Nazartinib

Biological Targets

EGFR

Associated Conditions

neoplasm·lung cancer·bronchial neoplasm·non-small cell lung carcinoma

* The information provided here is compiled from public sources and is for reference only.

Nazartinib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Nazartinib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Documentation

Nazartinib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy.

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.

Nazartinib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy.

Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.

Documentation