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Chemical structure of CAS 149503-79-7

Lefradafiban

In Stock•Starting at $258 for 1 mg
CAS No.149503-79-7
MDL No.N/A
MFC23H25N3O6
MW439.50
InChI KeyPGCFXITVMNNKON-ROUUACIJSA-N
CUSTOM SYNTHESIS

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mgTo Be Confirmed$258In Stock
5 mgTo Be Confirmed$622In Stock
10 mgTo Be Confirmed$870In Stock
25 mgTo Be Confirmed$1292In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

Lefradafiban is a pyrrolidin-2-one with the 3-pro-S-hydrogen substituted by a 2-methoxy-2-oxoethyl group and the 5-pro-S-hydrogen substituted by a ({4'-[N-(methoxycarbonyl)carbamimidoyl]biphenyl-4-yl}oxy)methyl group. It is an orally active prodrug of fradafiban, a fibrinogen receptor antagonist, and functions as a platelet glycoprotein-IIb/IIIa receptor antagonist. It is a methyl ester and a member of pyrrolidin-2-ones, and is functionally related to fradafiban.

CAS No.149503-79-7
Product NameLefradafiban
Heavy Atom Count32Rotatable Bond Count7
Atom Stereo Count2Bond Stereo Count1
HBA6HBD2
TPSA129.310 ŲCharge0
Exact Mass439.17434Complexity1001.40
pKa7.130XLogP2.272

Related Articles

Studies related to this compound and its mechanism of action

Clinical trials with glycoprotein IIb/IIIa antagonists - No benefit without bleeding?

Drugs of today (Barcelona, Spain : 1998) • Vol. 37, Issue 8 • 2001
PMID: 12743636DOI: 10.1358/dot.2001.37.8.844169

Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty.

Heart (British Cardiac Society) • Vol. 85, Issue 4 • 2001
PMID: 11250974PMC: PMC1729676DOI: 10.1136/heart.85.4.444

Documentation

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