PF-6409577

PF-06409577 is a 6-chloro-1H-indole substituted with a carboxy group at position 3 and a 4-(1-hydroxycyclobutyl)phenyl group at position 5. It is a potent and selective allosteric activator of AMPK and a potential treatment for diabetic nephropathy. It functions as an EC 2.7.11.31 (hydroxymethylglutaryl-CoA reductase (NADPH) kinase) activator, an antiatherosclerotic agent, an antineoplastic agent, and a nephroprotective agent. It belongs to the classes of benzenes, cyclobutanes, indolecarboxylic acids, chloroindoles, and tertiary alcohols.