HomeProductsBuilding BlocksHeterocyclic ScaffoldsAromatic HeterocyclesKetoconazole
Chemical structure of CAS 142128-57-2

Ketoconazole

In Stock•Starting at $36 for 1 mg•Purity ≥ 99.33%
CAS No.142128-57-2
MDL No.N/A
MFC26H28Cl2N4O4
MW531.40
InChI KeyXMAYWYJOQHXEEK-ZEQKJWHPSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mgTo Be Confirmed$36In Stock
2 mgTo Be Confirmed$51In Stock
5 mgTo Be Confirmed$83In Stock
100 mg99.33%$1374In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

(2S,4R)-Ketoconazole is a cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine with the dioxolane moiety in (2S,4R)-configuration. It is the enantiomer of (2R,4S)-ketoconazole.

CAS No.142128-57-2
Product NameKetoconazole

Biological Targets

CYP11A1·CYP11B1·CYP11B2·CYP17A1

Associated Conditions

adrenal gland disease·Cushing syndrome·type 2 diabetes mellitus·adrenal gland hyperfunction·pituitary-dependent Cushing's disease
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

Regulation of TNF-alpha by 1alpha,25-dihydroxyvitamin D3 in human macrophages from CAPD patients.

Kidney international • Vol. 59, Issue 1 • 2001
PMID: 11135059DOI: 10.1046/j.1523-1755.2001.00467.x

In the search for specific inhibitors of human 11beta-hydroxysteroid-dehydrogenases (11beta-HSDs): chenodeoxycholic acid selectively inhibits 11beta-HSD-I.

European journal of endocrinology • Vol. 142, Issue 2 • 2000
PMID: 10664531DOI: 10.1530/eje.0.1420200

Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells.

The Journal of biological chemistry • Vol. 275, Issue 47 • 2000
PMID: 10960482DOI: 10.1074/jbc.M006456200

Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.

Drug metabolism and disposition: the biological fate of chemicals • Vol. 28, Issue 10 • 2000
PMID: 10997946

Documentation

Similar Products