Gsk2656157

GSK2656157 is a pyrrolopyrimidine, specifically 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, substituted at position 5 with a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, whose nitrogen is acylated by a (6-methylpyridin-2-yl)acetyl group. It is an orally bioavailable PERK inhibitor with activity as a protein-tyrosine-phosphatase inhibitor and an antineoplastic agent. It belongs to the classes of biaryl, indole, methylpyridine, organofluorine, and tertiary carboxamide compounds.