Product Information

CAS No.	1234015-52-1
Product Name	Prexasertib

Biological Targets

CHEK1·CHEK2

Associated Conditions

neoplasm·brain cancer·metastasis·chronic myelomonocytic leukemia·cancer·

* The information provided here is compiled from public sources and is for reference only.

Studies related to this compound and its mechanism of action

Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors.

Chemico-biological interactions • Vol. 397 • 2024

PMID: 38795876 DOI: 10.1016/j.cbi.2024.111063

Exploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells.

Cell biology and toxicology • Vol. 39, Issue 3 • 2023

PMID: 34519926 PMC: PMC10406704 DOI: 10.1007/s10565-021-09640-x

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research • Vol. 23, Issue 15 • 2017

PMID: 28270495 DOI: 10.1158/1078-0432.CCR-16-2876

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.

Molecular cancer therapeutics • Vol. 14, Issue 9 • 2015

PMID: 26141948 DOI: 10.1158/1535-7163.MCT-14-1037

Prexasertib

CAS No.	1234015-52-1
MDL No.	MFCD25977016
MF	C₁₈H₁₉N₇O₂
MW	365.40
InChI Key	DOTGPNHGTYJDEP-UHFFFAOYSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	1234015-52-1
Product Name	Prexasertib

Biological Targets

CHEK1·CHEK2

Associated Conditions

neoplasm·brain cancer·metastasis·chronic myelomonocytic leukemia·cancer·

* The information provided here is compiled from public sources and is for reference only.

Prexasertib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Prexasertib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Documentation

Prexasertib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors.

Exploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells.

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.

Similar Products

Prexasertib dihydrochloride

Prexasertib mesylate monohydrate

Prexasertib

Pricing & Availability

Product Information

Biological Profile

Properties

Biological Targets

Associated Conditions

Related Articles

Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors.

Exploring the ATR-CHK1 pathway in the response of doxorubicin-induced DNA damages in acute lymphoblastic leukemia cells.

The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.

LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.

Similar Products

Prexasertib dihydrochloride

Prexasertib mesylate monohydrate

Documentation