Methods to improve efficacy in suicide gene therapy approaches: targeting prodrug-activating enzymes carboxypeptidase G2 and nitroreductase to different subcellular compartments.
Methods in molecular medicine • Vol. 90 • 2004
Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
Journal of medicinal chemistry • Vol. 47, Issue 10 • 2004
Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
Journal of medicinal chemistry • Vol. 46, Issue 9 • 2003
A novel vascular endothelial growth factor-directed therapy that selectively activates cytotoxic prodrugs.
British journal of cancer • Vol. 88, Issue 10 • 2003
