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Chemical structure of CAS 1207629-49-9

Gsk-2245035

In Stock•Starting at $255 for 1 mg•Purity ≥ 98%
CAS No.1207629-49-9
MDL No.N/A
MFC20H34N6O2
MW390.50
InChI KeyLFMPVTVPXHNXOT-HNNXBMFYSA-N
CUSTOM SYNTHESISPRECLINICAL SUPPORT→

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
1 mg98%$255In Stock
5 mg98%$634In Stock
10 mg98%$1011In Stock
25 mg98%$1893In Stock
50 mg98%$2944In Stock
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.1207629-49-9
Product NameGsk-2245035

Biological Targets

TLR7

Associated Conditions

asthma
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology.

Immunology • Vol. 160, Issue 1 • 2020
PMID: 32020584PMC: PMC7160657DOI: 10.1111/imm.13175

Safety and pharmacodynamics of intranasal GSK2245035, a TLR7 agonist for allergic rhinitis: A randomized trial.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology • Vol. 47, Issue 9 • 2017
PMID: 28681506DOI: 10.1111/cea.12974

Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.

Journal of medicinal chemistry • Vol. 59, Issue 5 • 2016
PMID: 26861551DOI: 10.1021/acs.jmedchem.5b01647

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement.

Clinical pharmacology and therapeutics • Vol. 98, Issue 4 • 2015
PMID: 26044169DOI: 10.1002/cpt.157

Documentation

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