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CAS No.	1207253-08-4
Product Name	Mk-1064

Health Hazard

Signal Word:Warning

HCode:H371-H373

PCode:P260-P264-P270-P308+P316-P319-P405-P501

Studies related to this compound and its mechanism of action

Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues.

Scientific reports • Vol. 12, Issue 1 • 2022

PMID: 35589803 PMC: PMC9120030 DOI: 10.1038/s41598-022-12601-x

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

Scientific reports • Vol. 6 • 2016

PMID: 27256922 PMC: PMC4891657 DOI: 10.1038/srep27147

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

ChemMedChem • Vol. 9, Issue 2 • 2014

PMID: 24376006 DOI: 10.1002/cmdc.201300447

Mk-1064

CAS No.	1207253-08-4
MDL No.	MFCD28502027
MF	C₂₄H₂₀ClN₅O₃
MW	461.90
InChI Key	CKTWQGHVNRYNCM-UHFFFAOYSA-N

CUSTOM SYNTHESIS PRECLINICAL SUPPORT

Pricing & Availability

Pack Size	Purity	Price	Availability	Action
-	-	On Request	On Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.	1207253-08-4
Product Name	Mk-1064

Health Hazard

Signal Word:Warning

HCode:H371-H373

PCode:P260-P264-P270-P308+P316-P319-P405-P501

Mk-1064

Pricing & Availability

Product Information

Safety Information

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Documentation

Mk-1064

Pricing & Availability

Product Information

Safety Information

Properties

Documentation

Mk-1064

Pricing & Availability

Product Information

Safety Information

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Related Articles

Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues.

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Documentation

Mk-1064

Pricing & Availability

Product Information

Safety Information

Properties

Related Articles

Orexin 2 receptor (OX2R) protein distribution measured by autoradiography using radiolabeled OX2R-selective antagonist EMPA in rodent brain and peripheral tissues.

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.

Documentation