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Chemical structure of CAS 1176760-49-8

Azd-4877

CAS No.1176760-49-8
MDL No.N/A
MFC28H33N5O2S
MW503.70
InChI KeySMFXSYMLJDHGIE-UHFFFAOYSA-N

Pricing & Availability

Pack SizePurityPriceAvailabilityAction
- -On RequestOn Request
Custom synthesis and bulk supply options are available upon request.

Product Information

CAS No.1176760-49-8
Product NameAzd-4877

Biological Targets

KIF11

Associated Conditions

acute myeloid leukemia·non-Hodgkins lymphoma·lymphoma·neoplasm·carcinoma·
* The information provided here is compiled from public sources and is for reference only.

Related Articles

Studies related to this compound and its mechanism of action

A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors.

Cancer chemotherapy and pharmacology • Vol. 69, Issue 1 • 2012
PMID: 21638123DOI: 10.1007/s00280-011-1667-z

Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia.

Investigational new drugs • Vol. 30, Issue 3 • 2012
PMID: 21494838PMC: PMC4205950DOI: 10.1007/s10637-011-9660-2

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.

Journal of medicinal chemistry • Vol. 54, Issue 19 • 2011
PMID: 21899292DOI: 10.1021/jm200629m

Documentation

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